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Mikhail Kusaykin

159 Pr-t 100-letiya Vladivostoka, Vladivostok, 690022

Pacific Institute of Bioorganic Chemistry FEB RAS

Phone: (74232)-310705

E-mail: mik@piboc.dvo.ru

Objective:

Scientist, Biochemistry

Education:

Graduated from Biological Department of Far East State University, Chair of Biochemistry (1994-1999). Vladivostok, Russia

1999-2003 Ph.D. student of Pacific Institute of Bioorganic Chemistry, specialisation «Biochemistry». Ph. D. thesis:«О-glycosyde hydrolases from marine invertebrates. Properties and specificity of fucoidanases, sulfatases and 1→3-β-D-glucanases».

Experience:

Senior Scientist, 2006 – present

Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia

Laboratory of Enzyme Chemistry

Researcher, 2004- 2006

Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia

Laboratory of Enzyme Chemistry

Junior scientist, 2003-2004

Pacific Institute of Bioorganic Chemistry FEB RAS, Vladivostok, Russia

Laboratory of Enzyme Chemistry

November 2002 – February 2003 Probation period at the Zelinsky Institute of Oganic Chemisty (Moscow)

Research Skills:

O-glycoside hyhrolases.

Enzymes of marine organisms transforming polysaccharids of brown alga: fucoidanase, 1,3-β-D-glucanase, sulfatase and others. Isolation, purification, biochemical properties and mechanism of action.

Research Grants

Personal research grant – RFBR (Russian Foundation for Basic Research) No 01-04-06200 (2000-2001) FEB RAS Grant (2005), Co-investigator RFBR 00-04-48946 (1999-2000), Federal program of integration science and education “INTEGRACIA” (2001), Grant of the Program Physical-Chemical Biology of Russian Academy of Science, FEB RAS Grant (2005), CRDF (REC-003), Ministry of Education and Science of Russia Grant RNP.2.2.2.3.1643

Publications:

  1. Burtseva Yu. V., Kusaykin M.I., Sova V.V., Shevchenko N.M., Skobun A.S., Zvyagintseva T.N. Distribution of fucoidan-hydrolases and some glycosidases among marine invertebrates // Biologia Morya. 2000. V. 26, No. 6. P. 429-432.

  1. Zvyagintseva T.N., Kusaykin M.I., Bacunina I.U., Scobun A.S., Shevchenko N.M.// Water soluble polysaccharides of some Far-Eastern seaweeds. Structure and enzymatic transformation. Abstracts of I0-th International Symposium on Marine Natural Products. Nago, Okinawa. 2001. P.106.

  1. Kusaykin M.I., Burtseva Yu.V., Sova V.V., Svetasheva T.G., Zvyagintseva T.N., Distribution of O-Glycosylhydrolases in marine invertebrates. Enzymes of the marine mollusk Littorina kurila that catalyze fucoidan transformation // Biochemistry (Moscow). 2003. V. 68, No. 3. P. 317-324.

  1. Sova V.V., Shirokova N.I., Kusaykin M.I., Scobun A.S., Elyakova L.A., Zvyagintseva T.N. β-1,3-Glucanase from unfertilized eggs of the sea urchin Strongylocentrotus intermedius. Comparison with β-1,3-glucanases of marine and terrestrial mollusks // Biochemistry (Moscow), 2003. V. 68. No. 5. P. 529-533.

  1. Bulgakov V.P., Kusaykin M.I., Tchernoded G., Zvyagintseva T.N., Zhuravlev Yu. The rolC-gene mediated changes of carbohydrase activities in the transformed ginseng tissues // Fitoterapia. 2002. V. 73. P.638-643.

  1. Kusaykin M.I., Chizhov A.O., Alekseeva S.A., Bakunina I.Yu., Nedashkovskaya O.I., Sova V.V., Zvyagintseva T.N. Comparative research of fucoidanases specificity marine microorganisms and marine invertebrates // Doklady Academii Nauk. 2004. V. 369. P. 1-3.

  1. A method of complex processing of the brown alga for medical and cosmetology substantial. Shevchenko N.M., Imbs T.I., Urvantseva A.M., Kusaykin M.I., Kornienko V.G., Zvyagintseva T.N., Elyakova L.A. Patent Russian Federation No. 2240816, C1, 2004.

  1. Alekseeva S.A., Shevchenko N.M., Kusaykin M.I., Ponomarenko L.P., Isakov V.V., Zvyagintseva T.N., Likhoshvai E.V. Polysaccharides of Diatoms Occurring in Lake Baikal // Applied Biochemistry and Microbiology (Moskow) 2005. V. 41. No. 2. P. 185–191.

  1. M.I. Kusaykin, A.O.Chizhov, A.A.Grachev, S.A.Alekseeva, I.Yu.Bakunina, V.V.Sova, O.I. Nedashkovskaya, T.N.Zvyagintseva. A comparative study of specificity of fucoidanases from marine microorganisms and invertebrates // J.Appl. Phycol. 2006. V.18. P.369-373.

  1. Kovalchuk S.N., Sundukova E.V., Kusaykin M.I., Guzev K.V., Anastyuk S.D., Likhatskaya G.N., Trifonov E.V.,Nurminski E.A., Kozhemyako V.B., Zvyagintseva T.N., Rasskazov V. A. Purification, cDNA cloning and homology modeling of endo-1,3-b-D-glucanase from scallop Mizuhopecten yessoensis. // Сomparative Biochem.Biophys. Part B 143. 2006. 473-485.

  1. M. I. Kusaykin, M. S. Pesentseva, A. S. Sil’chenko, S. A. Avilov, V. V. Sova, T. N. Zvyagintseva, and V. A. Stonik Aryl Sulfatase of Unusual Specificity from the Liver of Marine Mollusk Littorina kurila // Russian Journal of Bioorganic Chemistry, 2006, Vol. 32, No. 1, pp. 63–70

  1. KiselevKV, KusaykinMI, DubrovinaAS, BezverbnyDA, ZvyagintsevaTN, BulgakovVP. The rolC gene induces expression of a pathogenesis-related beta-1,3-glucanase in transformed ginseng cells. // Phytochemistry. 2006. V. 67. P. 2225-2231.

  1. Kusaykin, M.I., Bakunina, I.Yu., Sova, V.V., Ermakova, S.P., Kuznetsova, T.S., Besednova, N.N., Zaporozhets, T.S., Zvyagintseva, T.N. Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds // Biotechnol. J. 2008, Vol. 3., No.7., p. 904-915

  1. Pesentseva, M.S., Kusaykin, M.I., Anastyuk, S.D., Sova, V.V., Zvyagintseva, T.N. Catalytic properties and mode of action of endo-(1->3)-beta-d-glucanase and beta-d-glucosidase from the marine mollusk Littorina kurila // Carbohydr. Res., 2008, Vol. 343., p. 2393-2400

  1. Zakharenko A.M., Kusaykin M.I., Bui Minh Ly, Pham Van Huen, Hoang Khanh Khan, Sova V.V., Zvyagintseva T.N. Catalytic properties 1,3-beta-D-glucanase from vietnamise mitilus Perna viridis // Bioorg. Chem. (Moscow), 2009, V. 35, No. 1, p. 65-69

  1. Zakharenko A.M., Kusaykin M.I., Kovalchuk S.N., Bui Minh Ly, Anastyuk S.D., Sova V.V., Rasskazov V.A., Zvyagintseva T.N. Enzymatic and molecular characterization of an endo-1,3-β-D-glucanase from the crystalline styles of the mussel Perna viridis // Carbohydr. Res. 2010. (doi:10.1016/j.carres.2010.11.008)
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